Associations of diabesity with all-cause and cardiovascular disease mortality: Findings from the Mexico City Prospective Study
Autor
Petermann-Rocha, Fanny
Apolinar, Evelia
Nazar, Gabriela
Diaz-Toro, Felipe
Celis, Andrés
Deo, Salil
Ferrari, Gerson
O'Donovan, Gary
Resumen
Aim: To investigate the joint associations of diabetes and obesity with all-cause and cardiovascular disease (CVD) mortality in the Mexico City Prospective Study. Materials and Methods: In total, 154 128 participants (67.2% women) were included in this prospective analysis. Diabetes was self-reported, while body mass index was used to calculate obesity. Using diabetes and obesity classifications, six groups were created: (a) normal (no diabetes and normal weight); (b) normal weight and diabetes; (c) overweight but not diabetes (overweight); (d) overweight and diabetes (prediabesity); (e) obesity but not diabetes (obesity); and (f) obesity and diabetes (diabesity). Associations between these categories and outcomes were investigated using Cox proportional hazard models adjusted for confounder factors. Results: During 18.3 years of follow-up, 27 197 (17.6%) participants died (28.5% because of CV causes). In the maximally adjusted model, participants those with the highest risk {hazard ratio (HR): 2.37 [95% confidence interval (CI): 2.24-2.51]}, followed by those with diabesity [HR: 2.04 (95% CI: 1.94-2.15)]. Similar trends of associations were observed for CVD mortality. The highest CV mortality risk was observed in individuals with diabesity [HR: 1.80 (95% CI: 1.63-1.99)], followed by normal weight and diabetic individuals [HR: 1.78 (95% CI: 1.60-1.98)]. Conclusion: This large prospective study identified that diabetes was the main driver of all-cause and CVD mortality in all the categories studied, with diabesity being the riskiest. Given the high prevalence of both conditions in Mexico, our results reinforce the importance of initiating prevention strategies from an early age. © 2024 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Association between a lifestyle score and all-cause mortality: a prospective analysis of the Chilean National Health Survey 2009–2010 (2024)
Petermann-Rocha, Fanny; Diaz-Toro, Felipe; Troncoso-Pantoja, Claudia; Martínez-Sanguinetti, María Adela; Leiva-Ordoñez, Ana María; Nazar, Gabriela; Concha-Cisternas, Yeny; Martínez, Ximena Díaz; Lanuza, Fabian; Carrasco-Marín, Fernanda; ... (Cambridge University Press, 2024)Objective: To investigate the association between a lifestyle score and all-cause mortality in the Chilean population. Design: Prospective study. Settings: The score was based on seven modifiable behaviours: salt intake, ... -
Article
Lifestyle risk factors and all-cause and cause-specific mortality in the Mexico City prospective study: Assessing the influence of reverse causation (2024)
Ferrari, Gerson; de Maio Nascimento, Marcelo; Petermann-Rocha, Fanny; Rezende, Leandro F.M.; O'Donovan, Gary; Gouveia, Élvio R.; Cristi-Montero, Carlos; Marques, Adilson (Elsevier B.V., 2024)Background: We examined the association between individual lifestyle risk factors with all-cause and cause-specific mortality. Methods: Prospective cohort study including 155,002 participants from the Mexico City Prospective ... -
Article
Association of Sitting Time With All-Cause and Cardiovascular Mortality: How Does Frailty Modify This Association? (2024)
Diaz-Toro, Felipe; Nazal, Carolina Nazzal; Nazar, Gabriela; Diaz-Martinez, Ximena; Concha-Cisternas, Yeny; Celis-Morales, Carlos; Petermann-Rocha, Fanny (Human Kinetics Publishers Inc., 2024)To investigate how frailty modifies the association of sitting time with all-cause and cardiovascular mortality in Chilean adults. This prospective study included 2,604 participants aged ≥35 from the Chilean National Health ...