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Mentally-passive sedentary behavior and incident depression: Mediation by inflammatory markers
dc.contributor.author | Werneck, André O. | |
dc.contributor.author | Owen, Neville | |
dc.contributor.author | Araujo, Raphael H.O. | |
dc.contributor.author | Silva, Danilo R. | |
dc.contributor.author | Hallgren, Mats | |
dc.date.accessioned | 2024-04-18T07:30:47Z | |
dc.date.available | 2024-04-18T07:30:47Z | |
dc.date.issued | 2023 | |
dc.identifier | 10.1016/j.jad.2023.07.053 | |
dc.identifier.issn | 01650327 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/11199 | |
dc.description.abstract | Background: Sedentary behavior (SB; time spent sitting, as distinct from lack of exercise or physical activity) is associated with depression, yet little is known about the relationship between different types of SB (e.g., mentally-passive versus mentally-active) with depression and potential biological mediators of these associations. Methods: We used cohort data from the 1958 National Child Development Study (n = 4607; 50.4 % women), conducted in UK, employing the 44 y and 46 y waves as baseline, and the 50 y and 55 y waves as follow-up. Participants reported time spent in TV viewing and watching videos (mentally-passive SB); and, time sitting while doing light activities such as deskwork or driving a car during worktime (mentally-active SB). Depression diagnosis was self-reported during the initial and follow-up waves. Waist circumference, C-reactive protein, and glycated hemoglobin were examined as potential mediators. Results: Mentally-passive SB was associated with incident depression (HR: 1.43; 95%CI: 1.19; 1.71), while there was no association for mentally-active SB. Waist circumference (coefficient: −0.03; 95%CI: −0.05; −0.01; 9.2 %) and C-reactive protein (coefficient: −0.03; 95%CI: −0.04; −0.01; 8.3 %), but not glycated hemoglobin, partly mediated the association for mentally-passive SB. Conclusions: In the relationship of mentally-passive SB with incident depression, the mediating contributions of waist circumference and C-reactive protein point to possible inflammatory-related mechanisms. © 2023 The Author(s) | es_ES |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo, FAPESP, (2019/24124-7); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES, (88887.605034/2021-00) | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Elsevier B.V. | es_ES |
dc.subject | Depressive disorder | es_ES |
dc.subject | Physical activity | es_ES |
dc.subject | Sedentary lifestyle | es_ES |
dc.subject | Sedentary time | es_ES |
dc.subject | Sitting | es_ES |
dc.title | Mentally-passive sedentary behavior and incident depression: Mediation by inflammatory markers | es_ES |
dc.type | Article | es_ES |