Variability of the genetic marker CLOCK rs3749474 and its impact on research and clinical trials on obesity and circadian rhythm
Autor
Roco-Videla, Ángel
Flores, Sergio V.
Olguin-Barraza, Mariela
Maureira-Carsalade, Nelson
Resumen
Introduction: circadian rhythms influence eating behavior, with the CLOCK gene being one of those responsible for its regulation. The rs3749474T/C of the CLOCK gene has been associated with an increased risk of obesity. Those who carry the T allele have greater weight loss on a diet low in carbohydrates and lipids than those who have the CC form. Methodology: using the 1000 Genomes database, the genotype of the single nucleotide polymorphism (SNP) rs3749474 was obtained from 2,504 individuals, covering five macro-populations (Africa, East Asia, South Asia, Europe and Latin America) and 26 populations. CT and TT were treated as non-risk genotypes and CC as risk. Fisher’s exact test was used to compare the frequencies of risk and non-risk genotypes among the five macro populations. Results: there is a high differentiation for the frequency of genotypes carrying the T allele among the macro-populations: Africa reached only 31.47 %, Europe 56.86 %; Latin America 66.28 %; South Asia 68.3 % and East Asia 81.15 %, with significant differences (pFisher < 0.05) in all comparisons, except between Latin America and South Asia. Low heterogeneity was observed between populations within each macro population. Conclusions: the high heterogeneity for the genotypic frequencies of CLOCK rs3749474 in the studied macro-populations indicates that the decrease in the consumption of carbohydrates and lipids will have a heterogeneous impact, from the epidemiological point of view. This sug-gests including the genetic ancestry in later studies of association between circadian cycles, eating behavior and obesity, in order to develop personalized clinical tests. © 2022 SENPE and Arán Ediciones S.L.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Prevalence of the GA risk haplotype of the rs1554483 and rs4864548 polymorphisms of the CLOCK gene associated with obesity and overweight in 26 populations (2024)
Flores, Sergio; Roco-Videla, Ángel; Olguín-Barraza, Mariela; Maureira-Carsalade, Nelson (ARAN Ediciones S.L, 2023)Introduction: the GA haplotype of polymorphisms rs1554483 and rs4864548 has been associated with components of the metabolic syndrome such as high blood pressure and triglyceride levels; its carriers have a risk of obesity, ... -
Other
Statistical association between genetic markers and food addiction: Methodological considerations (2024)
Flores, Sergio V.; Roco-Videla, Ángel; Maureira-Carsalade, Nelson; Olguin-Barraza, Mariela (ARAN Ediciones S.L, 2023)[No abstract available] -
Other
The rs7139228 polymorphism is located in the DCN gene and not in the RETN gene (2024)
Flores, Sergio V.; Roco-Videla, Ángel; Olguin-Barraza, Mariela; Maureira-Carsalade, Nelson (ARAN Ediciones S.L, 2023)[No abstract available]