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The Use of Human Sterilized Crushed Tooth Particles Compared with BTCP Biomaterial and Empty Defects in Bone Formation inside Critical Rabbit Calvaria Sites
dc.contributor.author | Calvo-Guirado, José Luis | |
dc.contributor.author | Cabo-Pastor, Marta Belén | |
dc.contributor.author | Martínez-Martínez, Francisco | |
dc.contributor.author | Garcés-Villalá, Miguel Ángel | |
dc.contributor.author | de Carlos-Villafranca, Félix | |
dc.contributor.author | García-Carrillo, Nuria | |
dc.contributor.author | Fernández-Domínguez, Manuel | |
dc.date.accessioned | 2024-04-10T01:02:33Z | |
dc.date.available | 2024-04-10T01:02:33Z | |
dc.date.issued | 2023 | |
dc.identifier | 10.3390/bioengineering10060638 | |
dc.identifier.issn | 23065354 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/10554 | |
dc.description.abstract | This study aimed to assess the bone regeneration of critical-size defects in rabbit calvaria filled with freshly crushed extracted teeth, comparing them with BTCP biomaterial and empty sites. Materials and methods: Twenty-one female New Zealand rabbits were used in this study. Two critical-size defects 6 mm in size were created in the skull bone, each with a 3 mm separation between them. Three experimental groups were evaluated: Group A (human sterilized crushed teeth granules alone), Group B (Bioner Bone, Bioner Sitemas Implantológicos), and Group C (unfilled defects). The animals were sacrificed at 4 and 8 weeks. Evaluation of the samples involved histological and histomorphometric analyses with radiographic evaluation. The histological evaluation showed a higher volume reduction in Group A compared with Group B (p < 0.05) and Control. Group A showed the highest values for cortical closure and bone formation around the particles, followed by Group B and Group C (p < 0.05). Within the limitations of this animal study, we can conclude that the use of human tooth particles leads to increased bone formation and reduced connective tissue in critical-size defects in rabbit calvaria when compared to BTCP biomaterial. The calvarial model is a robust base for the evaluation of different biomaterials. © 2023 by the authors. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | MDPI | es_ES |
dc.subject | bone graft | es_ES |
dc.subject | bone substitutes | es_ES |
dc.subject | BTCP biomaterial | es_ES |
dc.subject | crushed teeth | es_ES |
dc.subject | dentin grinder | es_ES |
dc.subject | human sterilized crushed teeth | es_ES |
dc.subject | skull rabbits | es_ES |
dc.subject | tooth particles | es_ES |
dc.title | The Use of Human Sterilized Crushed Tooth Particles Compared with BTCP Biomaterial and Empty Defects in Bone Formation inside Critical Rabbit Calvaria Sites | es_ES |
dc.type | Article | es_ES |