Structural and functional brain changes in people with knee osteoarthritis: a scoping review
Autor
Salazar-Méndez, Joaquín
Cuyul-Vásquez, Iván
Viscay-Sanhueza, Nelson
Morales-Verdugo, Juan
Mendez-Rebolledo, Guillermo
Ponce-Fuentes, Felipe
Lluch-Girbés, Enrique
Resumen
Background. Knee osteoarthritis is a highly prevalent disease worldwide that leads to functional disability and chronic pain. It has been shown that not only changes are generated at the joint level in these individuals, but also neuroplastic changes are produced in different brain areas, especially in those areas related to pain perception, therefore, the objective of this research was to identify and compare the structural and functional brain changes in knee OA versus healthy subjects. Methodology. Searches in MEDLINE (PubMed), EMBASE, WOS, CINAHL, SCOPUS, Health Source, and Epistemonikos databases were conducted to explore the available evidence on the structural and functional brain changes occurring in people with knee OA. Data were recorded on study characteristics, participant characteristics, and brain assessment techniques. The methodological quality of the studies was analysed with Newcastle Ottawa Scale. Results. Sixteen studies met the inclusion criteria. A decrease volume of the gray matter in the insular region, parietal lobe, cingulate cortex, hippocampus, visual cortex, temporal lobe, prefrontal cortex, and basal ganglia was found in people with knee OA. However, the opposite occurred in the frontal lobe, nucleus accumbens, amygdala region and somatosensory cortex, where an increase in the gray matter volume was evidenced. Moreover, a decreased connectivity to the frontal lobe from the insula, cingulate cortex, parietal, and temporal areas, and an increase in connectivity from the insula to the prefrontal cortex, subcallosal area, and temporal lobe was shown. Conclusion. All these findings are suggestive of neuroplastic changes affecting the pain matrix in people with knee OA. Copyright 2023 Salazar-Méndez et al.
Colecciones
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Article
Structural Brain Alterations in Individuals Post-COVID-19: A Systematic Review (2024)
Morales-Verdugo, Juan; Lozano-Lozano, José Antonio; Pérez-Rojas, Francisco; Mendez-Rebolledo, Guillermo; Vásquez, Andrés Carreño (Universidad de la Frontera, 2023)Although COVID-19 is primarily considered a respiratory pathology, it has been observed to impact other bodily systems, including the nervous system. While several studies have investigated anatomical changes in brain ... -
Article
Attentional focus instructions for therapeutic exercise in people with musculoskeletal disorders. A scoping review (2022)
Castillo-Vejar, L.; Lizama-Fuentes, M.; Cuyul-Vásquez, Iván; Bascour-Sandoval, Claudio (Ediciones Doyma, S.L., 2022)Attentional focus instructions are verbal strategies that could maximize the effects of exercise. The objective of this review was to explore and synthesize the available evidence on the incorporation of attentional focus ... -
Article
Relationship between body composition and somatotype with dynamic postural balance in young basketball players (2024)
Rodriguez-Araya, Sebastián; Díaz-Vega, Martín; Méndez-Rebolledo, Guillermo; Valdés-Badilla, Pablo; Núñez-Espinosa, Cristian; Salazar Méndez, Joaquín; Guzman Muñoz, Eduardo (Federacion Espanola de Docentes de Educacion Fisica, 2023)Objective: The aim of this study was to determine the relationship between body composition and somatotype with dynamic postural balance in young basketball players. Methods: The sample included 33 young male athletes aged ...