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dc.contributor.authorBada, Lucía
dc.contributor.authorPereira, Renato B.
dc.contributor.authorPereira, David M.
dc.contributor.authorLores, Marta
dc.contributor.authorCeleiro, María
dc.contributor.authorQuezada, Elías
dc.contributor.authorUriarte, Eugenio
dc.contributor.authorGil-Longo, José
dc.contributor.authorViña, Dolores
dc.date.accessioned2024-04-10T00:32:09Z
dc.date.available2024-04-10T00:32:09Z
dc.date.issued2023
dc.identifier10.3390/molecules28010351
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/10470
dc.description.abstractThe genus Ulex comprises thirteen accepted species of perennial shrubs in the family Fabaceae. In Galicia (Spain) many of these are considered spontaneous colonizing species, which are easy to establish and maintain. Among them, Ulex gallii Planch. is used in traditional medicine for the same anti-infective, hypotensive and diuretic purposes as Ulex europaeus L., which is the most studied species. Likewise, some studies have described the antitumoral properties of several species. However, there are few scientific studies that justify the use of Ulex gallii Planch. and nothing has been reported about its composition to date. In our study, the entire plant was extracted with methanol and the crude extract was subjected to liquid phase extraction with distinct solvents, yielding three fractions: hexane (H), dichloromethane (D) and methanol (M), which were subsequently fractionated. The dichloromethane (D5, D7 and D8) and methanol (M4) sub-fractions showed antiproliferative activity on A549 (lung cancer) and AGS (stomach cancer) cell lines, and caspase 3/7 activity assessment and DNA quantification were also performed. Targeted analysis via UHPLC-QToF, in combination with untargeted analysis via MS-Dial, MS-Finder and Global Natural Products Social Molecular Networking (GNPS), allowed us to tentatively identify different metabolites in these sub-fractions, mostly flavonoids, that might be involved in their antiproliferative activity. © 2023 by the authors.es_ES
dc.description.sponsorshipCentro de investigación de Galicia; Erasmus + Doctorado USC, (UIDB/50006/2020, UIDP/50006/2020); European Commission, EC; Ministério da Ciência, Tecnologia e Ensino Superior, MCTES; Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia, (ED431B 2020/26); European Regional Development Fund, ERDF, (BIND-CS/2020); Fundació Catalana de Trasplantament, FCTes_ES
dc.language.isoenes_ES
dc.publisherMDPIes_ES
dc.subjectantitumorales_ES
dc.subjectflavonoidses_ES
dc.subjectmetabolomics toolses_ES
dc.subjectUlex galliies_ES
dc.subjectultra-high-performance liquid-chromatographyes_ES
dc.titlePhytochemical Analysis and Antiproliferative Activity of Ulex gallii Planch. (Fabaceae), a Medicinal Plant from Galicia (Spain)es_ES
dc.typeArticlees_ES


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