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Medium and long-term prognosis in hospitalised older adults with multimorbidity. A prospective cohort study
dc.contributor.author | Molina, Siena | |
dc.contributor.author | Martinez-Urrea, Ana | |
dc.contributor.author | Malik, Komal | |
dc.contributor.author | Libori, Ginebra | |
dc.contributor.author | Monzon, Helena | |
dc.contributor.author | Martínez-Camblor, Pablo | |
dc.contributor.author | Almagro, Pere | |
dc.date.accessioned | 2024-04-10T00:06:14Z | |
dc.date.available | 2024-04-10T00:06:14Z | |
dc.date.issued | 2023 | |
dc.identifier | 10.1371/journal.pone.0285923 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/10383 | |
dc.description.abstract | Background Data about long-term prognosis after hospitalisation of elderly multimorbid patients remains scarce. Objectives Evaluate medium and long-term prognosis in hospitalised patients older than 75 years of age with multimorbidity. Explore the impact of gender, age, frailty, physical dependence, and chronic diseases on mortality over a seven-year period. Methods We included prospectively all patients hospitalised for medical reasons over 75 years of age with two or more chronic illnesses in a specialised ward. Data on chronic diseases were collected using the Charlson comorbidity index and a questionnaire for disorders not included in this index. Demographic characteristics, Clinical Frailty Scale, Barthel index, and complications during hospitalisation were collected. Results 514 patients (46% males) with a mean age of 85 (± 5) years were included. The median follow- up was 755 days (interquartile range 25-75%: 76-1,342). Mortality ranged from 44% to 68%, 82% and 91% at one, three, five, and seven years. At inclusion, men were slightly younger and with lower levels of physical impairment. Nevertheless, in the multivariate analysis, men had higher mortality (p<0.001; H.R.:1.43; 95% C.I.95%:1.16-1.75). Age, Clinical Frailty Scale, Barthel, and Charlson indexes were significant predictors in the univariate and multivariate analysis (all p<0.001). Dementia and neoplastic diseases were statistically significant in the unadjusted but not the adjusted model. In a cluster analysis, three patterns of patients were identified, with increasing significant mortality differences between them (p<0.001; H.R.:1.67; 95% CI: 1.49-1.88). Conclusions In our cohort, individual diseases had a limited predictive prognostic capacity, while the combination of chronic illness, frailty, and physical dependence were independent predictors of survival. © 2023 Molina et al. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.title | Medium and long-term prognosis in hospitalised older adults with multimorbidity. A prospective cohort study | es_ES |
dc.type | Article | es_ES |