Mostrar el registro sencillo del ítem
UFR2709, an Antagonist of Nicotinic Acetylcholine Receptors, Delays the Acquisition and Reduces Long-Term Ethanol Intake in Alcohol-Preferring UChB Bibulous Rats
dc.contributor.author | Gálvez, Gabriel | |
dc.contributor.author | González-Gutiérrez, Juan Pablo | |
dc.contributor.author | Hödar-Salazar, Martín | |
dc.contributor.author | Sotomayor-Zárate, Ramón | |
dc.contributor.author | Quintanilla, María Elena | |
dc.contributor.author | Quilaqueo, María Elena | |
dc.contributor.author | Rivera-Meza, Mario | |
dc.contributor.author | Iturriaga-Vásquez, Patricio | |
dc.date.accessioned | 2022-07-13T16:09:23Z | |
dc.date.available | 2022-07-13T16:09:23Z | |
dc.date.issued | 2022-07 | |
dc.identifier | 10.3390/biomedicines10071482 | |
dc.identifier.issn | 22279059 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/10097 | |
dc.description.abstract | Alcoholism is a worldwide public health problem with high economic cost and which affects health and social behavior. It is estimated that alcoholism kills 3 million people globally, while in Chile it is responsible for around 9 thousand deaths per year. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels expressed in the central nervous system, and they were suggested to modulate the ethanol mechanism involved in abuse and dependence. Previous work demonstrated a short-term treatment with UFR2709, a nAChRs antagonist, which reduced ethanol intake using a two-bottle free-choice paradigm in University of Chile bibulous (UChB) rats. Here, we present evidence of the UFR2709 efficacy in reducing the acquisition and long-term ethanol consumption. Our results show that UFR2709 (2.5 mg/kg i.p.) reduces the seek behavior and ethanol intake, even when the drug administration was stopped, and induced a reduction in the overall ethanol intake by around 55%. Using naïve UChB bibulous rats, we demonstrate that UFR2709 could delay and reduce the genetically adaptive impulse to seek and drink ethanol and prevent its excessive intake. | es_ES |
dc.language.iso | en | es_ES |
dc.publisher | MDPI | es_ES |
dc.subject | nicotinic antagonist | es_ES |
dc.subject | UChB rats | es_ES |
dc.subject | UFR2709 | es_ES |
dc.subject | voluntary ethanol intake | es_ES |
dc.title | UFR2709, an Antagonist of Nicotinic Acetylcholine Receptors, Delays the Acquisition and Reduces Long-Term Ethanol Intake in Alcohol-Preferring UChB Bibulous Rats | es_ES |
dc.type | Article | es_ES |